Roughly 30 million Americans have used Ozempic or similar GLP-1 drugs, many for off-label weight loss despite Ozempic only being FDA-approved for treating Type 2 Diabetes. While related drugs like Wegovy and Saxenda have been approved for obesity, Ozempic’s rising popularity—fueled by celebrity use—has brought growing concern over its side effects.

A viral simulation video by YouTuber @ZackDFilms revealed how Ozempic works: it reduces appetite by activating brain receptors, slows stomach emptying to maintain fullness, and helps stabilize blood sugar. However, this can lead to nausea, diarrhea, and even frail skin from rapid weight loss—coined terms like “Ozempic face” and “Ozempic butt” reflect its visible effects.

Plastic surgeon Dr. Barry Weintraub noted that such drastic weight loss could also cause veins and tendons to become more visible, even in areas like the feet. These changes, seen in stars like Sharon Osbourne, have stirred alarm among fans and health professionals.

Experts like Dr. Ben Bickman warn of long-term issues like muscle and bone loss, and the risk of fat gain after stopping the drug. Studies suggest Ozempic might trigger new fat cell production, meaning users could end up with more body fat than before—even if they weigh less.

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